Infiltrating epitheliosis of the breast: characterization of histological features, immunophenotype and genomic profile.

ABSTRACT:

Aims

Infiltrating epitheliosis is a rare complex sclerosing lesion (CSL) of the breast, characterized by infiltrating ducts immersed in a scleroelastotic stroma and filled with cells having architectural and cytological patterns reminiscent of those of usual ductal hyperplasia. In this study we sought to define the molecular characteristics of infiltrating epitheliosis.

Methods and results

Eight infiltrating epitheliosis, adjacent breast lesions (one usual ductal hyperplasia, one papilloma, one micropapillary ductal carcinoma in situ and one low-grade adenosquamous carcinoma), and corresponding normal breast tissue from each case were microdissected and subjected to massively parallel sequencing analysis targeting all coding regions of 254 genes mutated recurrently in breast

SUBMITTER: Eberle CA 

PROVIDER: S-EPMC4957818 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature