In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin.

ABSTRACT:

Background

Anti-malarial drugs are the major focus in the prevention and treatment of malaria. Artemisinin-based combination therapy (ACT) is the WHO recommended first-line treatment for Plasmodium falciparum malaria across the endemic world. Also ACT is increasingly relied upon in treating Plasmodium vivax malaria where chloroquine is failing. The emergence of artemisinin drug-resistant parasites is a serious threat faced by global malaria control programmes. Therefore, the success of treatment and intervention strategies is highly pegged on understanding the genetic basis of resistance.

Methods

Here, resistance in P. falciparum was generated in vitro for artemisinin to produce levels above clinically relevant concentrations in vivo, and the molecular haplotypes investigate

SUBMITTER: Njokah MJ 

PROVIDER: S-EPMC4957835 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature