MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. Numerous studies have shown that miRNAs are not only key regulators in important cellular processes but are also drivers in the development of many diseases, especially cancer. Estrogen receptor positive luminal B is the second most common but the least studied subtype of breast cancer. Only a few studies have examined the expression profiles of miRNAs in luminal B breast cancer, and their regulatory roles in cancer progression have yet to be investigated.

Methods

In this study, using polyoma middle T antigen (PyMT) mice, a widely used luminal B breast cancer model, we profiled microRNA (miRNA) expression at four time points

SUBMITTER: Nogales-Cadenas R 

PROVIDER: S-EPMC4957901 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature