Shared and unique common genetic determinants between pediatric and adult celiac disease.

ABSTRACT:

Background

Based on age of presentation, celiac disease (CD) is categorised as pediatric CD and adult CD. It however remains unclear if these are genetically and/or phenotypically distinct disorders or just different spectrum of the same disease. We therefore explored the common genetic components underlying pediatric and adult CD in a well characterized north Indian cohort.

Methods

A retrospective analysis of children (n = 531) and adult (n = 871) patients with CD between January 2001 and December 2010 was done. The database included basic demographic characteristics, clinical presentations, associated diseases and complications, if any. The genotype dataset was acquired for children (n = 217) and adult CD patients (n = 340) and controls (n = 736) using Immunochip. Associat

SUBMITTER: Senapati S 

PROVIDER: S-EPMC4957920 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature