Flexibility Coexists with Shape-Persistence in Cyanostar Macrocycles.

ABSTRACT: Shape-persistent macrocycles are attractive functional targets for synthesis, molecular recognition, and hierarchical self-assembly. Such macrocycles are noncollapsible and geometrically well-defined, and they are traditionally characterized by having repeat units and low conformational flexibility. Here, we find it necessary to refine these ideas in the face of highly flexible yet shape-persistent macrocycles. A molecule is shape-persistent if it has a small change in shape when perturbed by external stimuli (e.g., heat, light, and redox chemistry). In support of this idea, we provide the first examination of the relationships between a macrocycle's shape persistence, its conformational space, and the resulting functions. We do this with a star-shaped macrocycle called cyanostar that is f

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4957974 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature