Fluff: exploratory analysis and visualization of high-throughput sequencing data.

ABSTRACT: In this article we describe fluff, a software package that allows for simple exploration, clustering and visualization of high-throughput sequencing data mapped to a reference genome. The package contains three command-line tools to generate publication-quality figures in an uncomplicated manner using sensible defaults. Genome-wide data can be aggregated, clustered and visualized in a heatmap, according to different clustering methods. This includes a predefined setting to identify dynamic clusters between different conditions or developmental stages. Alternatively, clustered data can be visualized in a bandplot. Finally, fluff includes a tool to generate genomic profiles. As command-line tools, the fluff programs can easily be integrated into standard analysis pipelines. The installation

SUBMITTER: Georgiou G 

PROVIDER: S-EPMC4957989 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature