Proteomic indicators of oxidation and hydration state in colorectal cancer.

ABSTRACT: New integrative approaches are needed to harness the potential of rapidly growing datasets of protein expression and microbial community composition in colorectal cancer. Chemical and thermodynamic models offer theoretical tools to describe populations of biomacromolecules and their relative potential for formation in different microenvironmental conditions. The average oxidation state of carbon (Z C) can be calculated as an elemental ratio from the chemical formulas of proteins, and water demand per residue ([Formula: see text]) is computed by writing the overall formation reactions of proteins from basis species. Using results reported in proteomic studies of clinical samples, many datasets exhibit higher mean Z C or [Formula: see text] of proteins in carcinoma or adenoma compared to nor

SUBMITTER: Dick JM 

PROVIDER: S-EPMC4958012 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature