Antifungal Properties of Cationic Phenylene Ethynylenes and Their Impact on β-Glucan Exposure.

ABSTRACT: Candida species are the cause of many bloodstream infections through contamination of indwelling medical devices. These infections account for a 40% mortality rate, posing a significant risk to immunocompromised patients. Traditional treatments against Candida infections include amphotericin B and various azole treatments. Unfortunately, these treatments are associated with high toxicity, and resistant strains have become more prevalent. As a new frontier, light-activated phenylene ethynylenes have shown promising biocidal activity against Gram-positive and -negative bacterial pathogens, as well as the environmental yeast Saccharomyces cerevisiae In this study, we monitored the viability of Candida species after treatment with a cationic conjugated polymer [poly(p-phenylene ethynylene); PP

SUBMITTER: Pappas HC 

PROVIDER: S-EPMC4958233 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature