CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus.

ABSTRACT:

Unlabelled

Staphylococcus aureus is the leading cause of skin and soft tissue infections, bacteremia, osteomyelitis, and endocarditis in the developed world. The ability of S. aureus to cause substantial disease in distinct host environments is supported by a flexible metabolism that allows this pathogen to overcome challenges unique to each host organ. One feature of staphylococcal metabolic flexibility is a branched aerobic respiratory chain composed of multiple terminal oxidases. Whereas previous biochemical and spectroscopic studies reported the presence of three different respiratory oxygen reductases (o type, bd type, and aa3 type), the genome contains genes encoding only two respiratory oxygen reductases, cydAB and qoxABCD Previous investigation showed that cydAB and qoxABCD

SUBMITTER: Hammer ND 

PROVIDER: S-EPMC4958251 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature