Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells.

ABSTRACT: Ageing is a process that inevitably affects most living organisms and involves the accumulation of macromolecular damage, genomic instability and loss of heterochromatin. Together, these alterations lead to a decline in stem cell function and to a reduced capability to regenerate tissue. In recent years, several genetic pathways and biochemical mechanisms that contribute to physiological ageing have been described, but further research is needed to better characterize this complex biological process. Because premature ageing (progeroid) syndromes, including progeria, mimic many of the characteristics of human ageing, research into these conditions has proven to be very useful not only to identify the underlying causal mechanisms and identify treatments for these pathologies, but also for t

SUBMITTER: Carrero D 

PROVIDER: S-EPMC4958309 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature