Treatment of catastrophic antiphospholipid syndrome.

ABSTRACT:

Purpose of review

Catastrophic antiphospholipid syndrome (CAPS) is a severe manifestation of antiphospholipid syndrome (APS). Although affecting only 1% of patients with APS, the condition is frequently fatal if not recognized and treated early. Here, we will review the current approach to diagnosis and treatment of CAPS.

Recent findings

Data from the international 'CAPS registry', spearheaded by the European Forum on Antiphospholipid Antibodies, have improved our understanding of at-risk patients, typical clinical features, and precipitating diagnoses. Current guidelines also continue to support the role of anticoagulants and glucocorticoids as foundation therapy in all patients. Finally, new basic science and case series suggest that novel therapies, such as rituximab and

SUBMITTER: Kazzaz NM 

PROVIDER: S-EPMC4958413 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature