Limbal Basal Cell Density Decreases in Limbal Stem Cell Deficiency.

ABSTRACT:

Purpose

To investigate changes in limbal basal epithelial cell density in eyes with limbal stem cell deficiency (LSCD) using in vivo confocal laser scanning microscopy.

Design

Retrospective observational comparative study.

Methods

A total of 43 eyes of 30 patients diagnosed with LSCD were included in the study. Ten eyes from normal subjects were included as control. Confocal imaging of the central cornea, and the superior, nasal, inferior and temporal limbus were collected using the Heidelberg Retina Tomograph III Rostock Corneal Module. Basal cell density in all locations was measured by 2 independent observers.

Results

The mean basal cell density of the normal group was 9264 ± 598 cells/mm(2) in the cornea and 7120 ± 362 cells/mm(2) in the limbus. In the LSCD

SUBMITTER: Chan EH 

PROVIDER: S-EPMC4958454 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature