Vascular morphology differentiates prostate cancer mortality risk among men with higher Gleason grade.

ABSTRACT:

Background

Higher Gleason grade is associated with prostate cancer mortality; however, there is significant heterogeneity in this association. We evaluated whether vessel morphology, a biomarker of angiogenesis, aided in distinguishing mortality risks among men with high Gleason grading.

Methods

We characterized vessel morphology (area and irregularity) among 511 patients diagnosed with prostate cancer during 1986 to 2000, re-reviewed Gleason grade, and followed men through 2012. Men were grouped according to integrated vessel lumen irregularity and vessel area across Gleason grade. The more angiogenic group was identified as those with more irregular vessel lumen and smaller vessel area. Crude rates (95 % confidence intervals) and survival probability were estimated across

SUBMITTER: Yang M 

PROVIDER: S-EPMC4958547 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature