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XPA: A key scaffold for human nucleotide excision repair.

ABSTRACT: Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.

SUBMITTER: Sugitani N 

PROVIDER: S-EPMC4958585 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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XPA: A key scaffold for human nucleotide excision repair.

Sugitani Norie N   Sivley Robert M RM   Perry Kelly E KE   Capra John A JA   Chazin Walter J WJ  

DNA repair 20160520

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA. ...[more]

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