Association of Itraconazole, a Hedgehog Inhibitor, and Bladder Cancer.

ABSTRACT:

Purpose

Activation of Hedgehog (Hh) signaling has been implicated in early stages of bladder cancer development while loss of Hh signaling has been described during progression to more invasive disease. Itraconazole, an antifungal, is the only azole known to be a potent Hh pathway antagonist. We evaluated whether itraconazole use is associated with bladder cancer risk or progression.

Materials and methods

We performed a case-control study nested in a United Kingdom database in 13,440 bladder cancer cases and 52,421 matched controls between 1995 and 2013. The use of itraconazole and other azoles was measured as the number of prescriptions. Conditional logistic regression was used for estimated AORs and the 95% CI of the association of bladder cancer with ever use and an incre

SUBMITTER: Mamtani R 

PROVIDER: S-EPMC4958604 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature