Loss of δ-GABA_A receptor-mediated tonic currents in the adult prelimbic cortex following adolescent alcohol exposure.

ABSTRACT: Delayed maturation of the adolescent prefrontal cortex may render it particularly vulnerable to insults, including those associated with drugs of abuse. Using a rat model of binge alcohol exposure, the present study examined the effect of adolescent intermittent ethanol (AIE) exposure during postnatal days 28-42 on γ-aminobutyric acid (GABA)ergic neurotransmission in the prelimbic cortex. In control rats, patch-clamp electrophysiology in acute slices obtained at different postnatal ages revealed a developmental increase in the GABA_A receptor-mediated tonic current in layer V pyramidal neurons but no change in layers II/III when measured in the adult. In slices from AIE-exposed rats, the amplitude of the tonic current was significantly reduced compared with controls when tested a

SUBMITTER: Centanni SW 

PROVIDER: S-EPMC4958607 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature