The molecular characteristics of colonic neoplasms in serrated polyposis: a systematic review and meta-analysis.

ABSTRACT: Serrated polyposis is a rare disorder characterised by the presence of multiple serrated polyps in the large intestine, and an increased personal and familial risk of colorectal cancer. Knowledge of the molecular characteristics of colonic lesions which develop in this syndrome is fragmented, making it difficult to understand the underlying genetic basis of this condition. We conducted a systematic review and meta-analysis of all studies which evaluated the molecular characteristics of colorectal neoplasms found in individuals with serrated polyposis. We identified 4561 potentially relevant studies, but due to a lack of consensus in the reporting of findings, only fourteen studies were able to be included in the meta-analysis. BRAF mutation was found in 73% (95% CI 65-80%) of serrated poly

SUBMITTER: He EY 

PROVIDER: S-EPMC4958734 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature