Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective.

ABSTRACT: The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject of active research for the past three decades. Although discrete evidence exists on various aspects of FXIII activation and regulation a combinatorial structure/functional view in this regard is lacking. In this study, we present results of a structure/function study of the functional chain of events for FXIII. Our study shows how subtle chronological submolecular changes within calcium binding sites can bring about the detailed transformation of the zymogenic FXIII to its activated form especially in the context of FXIIIA and FXIIIB subunit interactions. We demonstrate what aspects of FXIII are important for the stabilization (first calcium binding site) of its zymogenic form and the possible mod

SUBMITTER: Gupta S 

PROVIDER: S-EPMC4958977 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature