Clusters of Antibiotic Resistance Genes Enriched Together Stay Together in Swine Agriculture.

ABSTRACT:

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Antibiotic resistance is a worldwide health risk, but the influence of animal agriculture on the genetic context and enrichment of individual antibiotic resistance alleles remains unclear. Using quantitative PCR followed by amplicon sequencing, we quantified and sequenced 44 genes related to antibiotic resistance, mobile genetic elements, and bacterial phylogeny in microbiomes from U.S. laboratory swine and from swine farms from three Chinese regions. We identified highly abundant resistance clusters: groups of resistance and mobile genetic element alleles that cooccur. For example, the abundance of genes conferring resistance to six classes of antibiotics together with class 1 integrase and the abundance of IS6100-type transposons in three Chinese regions are directly c

SUBMITTER: Johnson TA 

PROVIDER: S-EPMC4959523 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature