Association between cyclin D1 G870A polymorphism and hepatocellular carcinoma risk: a meta-analysis.

ABSTRACT:

Background

Cyclin D1 (CCND1) G870A polymorphism may be associated with hepatocellular carcinoma (HCC) risk, but the results of previous studies were inconsistent. Available evidence was meta-analyzed to assess their potential association.

Methods

Databases PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature database, China National Knowledge Infrastructure, and Google Scholar were systematically searched. Meta-analyses were performed to investigate the association of G870A polymorphism with HCC risk by calculating odds ratios (ORs) and 95% confidence intervals (CIs) from the data of relevant case-control studies.

Results

Results of this meta-analysis of six case-control studies involving 1,030 cases and 1,683 controls indicate that G870A po

SUBMITTER: Luo T 

PROVIDER: S-EPMC4959597 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature