A Comprehensive Analysis of the Impact of HIV on HCV Immune Responses and Its Association with Liver Disease Progression in a Unique Plasma Donor Cohort.

ABSTRACT:

Objective

Human Immunodeficiency Virus (HIV) and Hepatitis C virus (HCV) co-infection is recognized as a major cause of morbidity and mortality among HIV-1 infected patients. Our understanding of the impact of HIV infection on HCV specific immune responses and liver disease outcome is limited by the heterogeneous study populations with genetically diverse infecting viruses, varying duration of infection and anti-viral treatment.

Methods

Viral-specific immune responses in a cohort of 151 HCV mono- and HIV co-infected former plasma donors infected with a narrow source of virus were studied. HCV and HIV specific T cell responses were correlated with clinical data.

Results

HIV-1 accelerated liver disease progression and decreased HCV specific T cell immunity. The magnitud

SUBMITTER: Zhang YH 

PROVIDER: S-EPMC4959707 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature