Role of Adiponectin in Coronary Heart Disease Risk: A Mendelian Randomization Study.

ABSTRACT:

Rationale

Hypoadiponectinemia correlates with several coronary heart disease (CHD) risk factors. However, it is unknown whether adiponectin is causally implicated in CHD pathogenesis.

Objective

We aimed to investigate the causal effect of adiponectin on CHD risk.

Methods and results

We undertook a Mendelian randomization study using data from genome-wide association studies consortia. We used the ADIPOGen consortium to identify genetic variants that could be used as instrumental variables for the effect of adiponectin. Data on the association of these genetic variants with CHD risk were obtained from CARDIoGRAM (22 233 CHD cases and 64 762 controls of European ancestry) and from CARDIoGRAMplusC4D Metabochip (63 746 cases and 130 681 controls; ≈ 91% of European ancestr

SUBMITTER: Borges MC 

PROVIDER: S-EPMC4959825 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature