Correlation of Optical Coherence Tomography and Autofluorescence in the Outer Retina and Choroid of Patients With Choroideremia.

ABSTRACT:

Purpose

To evaluate the relationships between RPE, photoreceptor, and choroidal degeneration in choroideremia.

Methods

Enhanced-depth imaging optical coherence tomography (EDI-OCT), scanning laser ophthalmoscopy (SLO), and autofluorescence (AF) were performed on 39 patients (78 eyes) with choroideremia. The edges of surviving outer retina on OCT and residual AF were aligned. The distribution of outer retinal tubulations was mapped over a range of ages (16-71 years), and comparison made between pre- and postsubretinal gene therapy. Subfoveal choroidal thickness (SFCT) was compared between 23 choroideremia patients (42 eyes) and 20 age- and refraction-matched male controls (40 eyes).

Results

The edges of RPE AF aligned with a reduction in outer nuclear layer thickness (

SUBMITTER: Xue K 

PROVIDER: S-EPMC4959839 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature