Defining a Valid Age Cutoff in Staging of Well-Differentiated Thyroid Cancer.

ABSTRACT:

Background

Age 45 years is used as a cutoff in the staging of well-differentiated thyroid cancer (WDTC) as it represents the median age of most datasets. The aim of this study was to determine a statistically optimized age threshold using a large dataset of patients treated at a comprehensive cancer center.

Methods

Overall, 1807 patients with a median follow-up of 109 months were included in the study. Recursive partitioning was used to determine which American Joint Committee on Cancer (AJCC) variables were most predictive of disease-specific death, and whether a different cutoff for age would be found. From the resulting tree, a new age cutoff was picked and patients were restaged using this new cutoff.

Results

The 10-year disease-specific survival (DSS) by Union fo

SUBMITTER: Nixon IJ 

PROVIDER: S-EPMC4959904 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature