The effective connectivity of the seizure onset zone and ictal perfusion changes in amygdala kindled rhesus monkeys.

ABSTRACT: Epileptic seizures are network-level phenomena. Hence, epilepsy may be regarded as a circuit-level disorder that cannot be understood outside this context. Better insight into the effective connectivity of the seizure onset zone and the manner in which seizure activity spreads could lead to specifically-tailored therapies for epilepsy. We applied the electrical amygdala kindling model in two rhesus monkeys until these animals displayed consistent stage IV seizures. At this stage, we investigated the effective connectivity of the amygdala by means of electrical microstimulation during fMRI (EM-fMRI). In addition, we imaged changes in perfusion during a seizure using ictal SPECT perfusion imaging. The spatial overlap between the connectivity network and the ictal perfusion network was assess

SUBMITTER: Cleeren E 

PROVIDER: S-EPMC4959940 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature