Modulation of urokinase plasminogen activator system by poly(ADP-ribose)polymerase-1 inhibition.

ABSTRACT: The urokinase plasminogen activator (uPA) system is a complex regulator of extracellular proteolysis which is involved in various physiological and pathological processes. The major components of this system are the serine protease uPA, two inhibitors PAI-1 and PAI-2, and the receptor uPAR. It has been previously shown by several groups that the uPA system has an important role in cancer progression and therefore its possible prognostic and therapeutic value has been evaluated. The aim of this study is to tackle the role of poly(ADP-ribosyl)ation in the induction of uPA activity in a glioblastoma cell line, A1235. This cell line is sensitive to alkylation damage and is a model for drug treatment. The components of the uPA system and the level of DNA damage were analyzed after alkylation ag

SUBMITTER: Madunic J 

PROVIDER: S-EPMC4960128 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature