Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine.

ABSTRACT: Pain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light, and sound) has been extensively reported. However, migraine may feature a more general enhanced response to aversive stimuli rather than being sensory-specific. To this end we used functional magnetic resonance imaging to assess neural activation in migraineurs interictaly in response to emotional visual stimuli from the International Affective Picture System. Migraineurs, compared to healthy controls, demonstrated increased neural activity in response to negative emotional stimuli. Most notably in regions overlapping in their involvement in both nociceptive and emotional processing including the posterior c

SUBMITTER: Wilcox SL 

PROVIDER: S-EPMC4960233 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature