Personalized Clinical Trials in Hepatocellular Carcinoma Based on Biomarker Selection.

ABSTRACT:

Background

Since the approval of sorafenib there have been numerous failures of new agents in Phase III studies for treatment of advanced hepatocellular carcinoma (HCC). These studies have generally ignored the molecular heterogeneity of HCC and they have not enrolled patients based on predictive markers of response. The development of molecular targeted therapeutics in HCC needs to model the approach that has been taken with great success in other solid tumors, to decrease the likelihood of failure in future studies.

Summary

Here we review the paradigm taken with novel targeted agents in other solid tumors and highlight ongoing studies in HCC that are incorporating biomarkers in clinical development.

Key messages

With the appreciation of the molecular diversity of HC

SUBMITTER: Zhang B 

PROVIDER: S-EPMC4960351 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature