Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals.

ABSTRACT:

Background

Reported associations between Tumor Necrosis Factor-alpha (TNFA) and the postprandial triacylglycerol (TAG) response have been inconsistent, which could be due to variations in the TNFA gene, meal fat composition or participant's body weight. Hence, we investigated the association of TNFA polymorphism (-308G → A) with body mass index (BMI) and postprandial lipaemia and also determined the impact of BMI on the association of the polymorphism with postprandial lipaemia.

Methods

The study participants (n = 230) underwent a sequential meal postprandial study. Blood samples were taken at regular intervals after a test breakfast (t = 0, 49 g fat) and lunch (t =330 min, 29 g fat) to measure fasting and postprandial lipids, glucose and insulin. The Metabolic Challenge Stu

SUBMITTER: Jackson KG 

PROVIDER: S-EPMC4960705 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature