A cohort analysis of men with a family history of BRCA1/2 and Lynch mutations for prostate cancer.

ABSTRACT:

Background

Prostate cancer (PC) is a major health concern for men worldwide, with an estimated lifetime risk of ~14 %. A recent comprehensive analysis of mutational processes revealed ageing and mismatch repair as the only altered processes in PC. We wish to test if a cohort of men with inherited risk of mismatch repair defect through BRCA1/2 or Lynch Syndrome mutations represents a target population for prostate cancer testing.

Methods

Fifty-eight men (aged 40-69 years) from families with a history of BRCA1/2 or HNPCC/Lynch mutations were invited to take part. Men with PSA >3.0 ng/ml were recommended to have transrectal ultrasound-guided prostatic biopsies.

Results

Overall 1 of 7 (14 %) and 1 of 20 (5 %) men with BRCA1/2 mutations were positive for a diagnosis of pro

SUBMITTER: Kerr L 

PROVIDER: S-EPMC4960816 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature