The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer.

ABSTRACT:

Background

Binding to Sema4D and PlexinB1 induce angiogenesis and invasive growth in colorectal cancer (CRC). The expression of Semaphorin4D (Sema4D) and PlexinB1 has been shown to be related to the prognosis of patients with various malignancies. However, the correlation between the expression of Sema4D and PlexinB1 and the relapse-free survival in patients with colorectal cancer remains controversial.

Methods

The study population included patients who underwent surgery for colorectal cancer (n = 226). The expression of Sema4D and PlexinB1 were analyzed by immunohistochemistry in tissue of stage I, II, and III colon cancers.

Results

The immunohistochemical staining of colorectal cancer tissue specimens revealed that 95 (42 %) and 105 (46.4 %) of the specimens were po

SUBMITTER: Ikeya T 

PROVIDER: S-EPMC4960918 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature