Dataset Information

Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China.

ABSTRACT:

Background

Over the years, the mechanical ventilation (MV) strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation (LPV), among brain-injured patients in China.

Methods

This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units (ICUs) across China. Mechanically ventilated patients (18 years and older) with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV.

Results

A total of 104 patients were enrolled in the present study, 87 (83.7%) of whom were identified with severe brain injury based on a Glasgow Coma Scale ≤8 points. Synchronized intermittent mandatory ventilation (SIMV) was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg (interquartile range [IQR], 7.0-8.9 ml/kg) of the predicted body weight; 50 (48.1%) patients received LPV. The median positive end-expiratory pressure (PEEP) was set to 5 cmH2O (IQR, 5-6 cmH2O). No PEEP values were higher than 10 cmH2O. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not.

Conclusions

Among brain-injured patients in China, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.

Trial registration

ClinicalTrials.org NCT02517073 https://clinicaltrials.gov/ct2/show/NCT02517073.

SUBMITTER: Luo XY

PROVIDER: S-EPMC4960952 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Publications

Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China.

Luo Xu-Ying XY Hu Ying-Hong YH Cao Xiang-Yuan XY Kang Yan Y Liu Li-Ping LP Wang Shou-Hong SH Yu Rong-Guo RG Yu Xiang-You XY Zhang Xia X Li Bao-Shan BS Ma Zeng-Xiang ZX Weng Yi-Bing YB Zhang Heng H Chen De-Chang DC Chen Wei W Chen Wen-Jin WJ Chen Xiu-Mei XM Du Bin B Duan Mei-Li ML Hu Jin J Huang Yun-Feng YF Jia Gui-Jun GJ Li Li-Hong LH Liang Yu-Min YM Qin Bing-Yu BY Wang Xian-Dong XD Xiong Jian J Yan Li-Mei LM Yang Zheng-Ping ZP Dong Chen-Ming CM Wang Dong-Xin DX Zhan Qing-Yuan QY Fu Shuang-Lin SL Zhao Lin L Huang Qi-Bing QB Xie Ying-Guang YG Huang Xiao-Bo XB Zhang Guo-Bin GB Xu Wang-Bin WB Xu Yuan Y Liu Ya-Ling YL Zhao He-Ling HL Sun Rong-Qing RQ Sun Ming M Cheng Qing-Hong QH Qu Xin X Yang Xiao-Feng XF Xu Ming M Shi Zhong-Hua ZH Chen Han H He Xuan X Yang Yan-Lin YL Chen Guang-Qiang GQ Sun Xiu-Mei XM Zhou Jian-Xin JX

Chinese medical journal 20160701 14

<h4>Background</h4>Over the years, the mechanical ventilation (MV) strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation (LPV), among brain-injured patients in China.<h4>Methods</h4>This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units (ICUs) across China. Mechanically ventilated patients (18 years and older) with brain injury in a participating ICU during the time of the st ...[more]

PMID: 27411450

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Dataset Information

Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China.

Background

Methods

Results

Conclusions

Trial registration

Publications

Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China.

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