Efficacy and Safety of Esmolol in Treatment of Patients with Septic Shock.

ABSTRACT:

Background

Previous studies have suggested that β1-receptor blockers benefit septic shock patients. This study aimed to determine whether β1-receptor blockers benefit tissue perfusion in sepsis and to identify parameters to reduce the risk of this drug in sepsis.

Methods

Consecutive septic shock patients were recruited from the Intensive Care Unit of Peking Union Medical College Hospital within 48 h of diagnosis. All patients were hemodynamically stable and satisfactorily sedated with a heart rate (HR) ≥100 beats/min. Esmolol therapy achieved the target HR of 10-15% lower than the baseline HR. Clinical and physiological data of patients were collected prospectively within 1 h prior to esmolol therapy and 2 h after achieving the targeted HR.

Results

Sixty-three patient

SUBMITTER: Du W 

PROVIDER: S-EPMC4960954 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature