Hepatic Perfusion Alterations in Septic Shock Patients: Impact of Early Goal-directed Therapy.

ABSTRACT:

Background

Early goal-directed therapy (EGDT) has become an important therapeutic management in early salvage stage of septic shock. However, splenic organs possibly remained hypoperfused and hypoxic despite fluid resuscitation. This study aimed to evaluate the effect of EGDT on hepatic perfusion in septic shock patients.

Methods

A prospective observational study was carried out in early septic shock patients who were admitted to Intensive Care Unit within 24 h after onset and who met all four elements of the EGDT criteria after treatment with the standard EGDT procedure within 6 h between December 1, 2012 and November 30, 2013. The hemodynamic data were recorded, and oxygen metabolism and hepatic functions were monitored. An indocyanine green clearance test was applied to d

SUBMITTER: Zhang XW 

PROVIDER: S-EPMC4960955 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature