Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis.

ABSTRACT:

Objective

Aberrant expression of ten-eleven translocation 1 (TET1) plays a critical role in tumor development and progression. We systematically summarized the latest research progress on the role and mechanisms of TET1 in cancer biology.

Data sources

Relevant articles published in English from 1980 to April 2016 were selected from the PubMed database. The terms "ten-eleven translocation 1," "5mC," "5hmC," "microRNA," "hypoxia," and "embryonic stem cell" were used for the search.

Study selection

Articles focusing on the role and mechanism of TET1 in tumor were reviewed, including clinical and basic research articles.

Results

TET proteins, the key enzymes converting 5-methylcytosine to 5-hydroxymethylcytosine, play vital roles in DNA demethylation regulation. Re

SUBMITTER: Tian YP 

PROVIDER: S-EPMC4960967 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature