FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.

ABSTRACT:

Rationale

Forkhead box-O transcription factors (FoxOs) transduce a wide range of extracellular signals, resulting in changes in cell survival, cell cycle progression, and several cell type-specific responses. FoxO1 is expressed in many cell types, including endothelial cells (ECs). Previous studies have shown that Foxo1 knockout in mice results in embryonic lethality at E11 because of impaired vascular development. In contrast, somatic deletion of Foxo1 is associated with hyperproliferation of ECs. Thus, the precise role of FoxO1 in the endothelium remains enigmatic.

Objective

To determine the effect of endothelial-specific knockout and overexpression of FoxO1 on vascular homeostasis.

Methods and results

We show that EC-specific disruption of Foxo1 in mice phenocopies

SUBMITTER: Dharaneeswaran H 

PROVIDER: S-EPMC4961050 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature