Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells.

ABSTRACT: Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.

SUBMITTER: Hou S 

PROVIDER: S-EPMC4961214 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature