Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin's Lymphoma.

ABSTRACT:

Background

We tested interim positron-emission tomography-computed tomography (PET-CT) as a measure of early response to chemotherapy in order to guide treatment for patients with advanced Hodgkin's lymphoma.

Methods

Patients with newly diagnosed advanced classic Hodgkin's lymphoma underwent a baseline PET-CT scan, received two cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) chemotherapy, and then underwent an interim PET-CT scan. Images were centrally reviewed with the use of a 5-point scale for PET findings. Patients with negative PET findings after two cycles were randomly assigned to continue ABVD (ABVD group) or omit bleomycin (AVD group) in cycles 3 through 6. Those with positive PET findings after two cycles received BEACOPP (bleomycin, etoposide

SUBMITTER: Johnson P 

PROVIDER: S-EPMC4961236 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature