The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

ABSTRACT: Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia. Tumour-secreted proteins play a crucial role in these interactions and present strategic therapeutic potential. Metastasis of breast cancer to the bone affects approximately 85% of patients with advanced disease and renders them largely untreatable. Specifically, osteolytic bone lesions, where bone is destroyed, lead to debilitating skeletal complications and increased patient morbidity and mortality. The molecular interactions governing the early events of osteolytic lesion formation are currently unclear. Here we show hypoxia to be specifically associated with bone relapse

SUBMITTER: Cox TR 

PROVIDER: S-EPMC4961239 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature