Global and local structural similarity in protein-protein complexes: implications for template-based docking.

ABSTRACT: The increasing amount of structural information on protein-protein interactions makes it possible to predict the structure of protein-protein complexes by comparison/alignment of the interacting proteins to the ones in cocrystallized complexes. In the predictions based on structure similarity, the template search is performed by structural alignment of the target interactors with the entire structures or with the interface only of the subunits in cocrystallized complexes. This study investigates the scope of the structural similarity that facilitates the detection of a broad range of templates significantly divergent from the targets. The analysis of the target-template similarity is based on models of protein-protein complexes in a large representative set of heterodimers. The similarity

SUBMITTER: Kundrotas PJ 

PROVIDER: S-EPMC4961257 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature