The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults.

ABSTRACT:

Background and objective

Recently, we have shown that the Parkinson's disease (PD) susceptibility locus MAPT (microtubule associated protein tau) is associated with parkinsonism in older adults without a clinical diagnosis of PD. In this study, we investigated the relationship between parkinsonian signs and MAPT transcripts by assessing the effect of MAPT haplotypes on alternative splicing and expression levels of the most common isoforms in two prospective clinicopathologic studies of aging.

Materials and methods

using regression analysis, controlling for age, sex, study and neuropathology, we evaluated 976 subjects with clinical, genotyping and brain pathology data for haplotype analysis. For transcript analysis, we obtained MAPT gene and isoform-level expression from the

SUBMITTER: Valenca GT 

PROVIDER: S-EPMC4961370 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature