Conservation of Distinct Genetically-Mediated Human Cortical Pattern.

ABSTRACT: The many subcomponents of the human cortex are known to follow an anatomical pattern and functional relationship that appears to be highly conserved between individuals. This suggests that this pattern and the relationship among cortical regions are important for cortical function and likely shaped by genetic factors, although the degree to which genetic factors contribute to this pattern is unknown. We assessed the genetic relationships among 12 cortical surface areas using brain images and genotype information on 2,364 unrelated individuals, brain images on 466 twin pairs, and transcriptome data on 6 postmortem brains in order to determine whether a consistent and biologically meaningful pattern could be identified from these very different data sets. We find that the patterns revealed b

SUBMITTER: Peng Q 

PROVIDER: S-EPMC4961377 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature