Altered Blood Biomarker Profiles in Athletes with a History of Repetitive Head Impacts.

ABSTRACT: The long-term health effects of concussion and sub-concussive impacts in sport are unknown. Growing evidence suggests both inflammation and neurodegeneration are pivotal to secondary injury processes and the etiology of neurodegenerative diseases. In the present study we characterized circulating brain injury and inflammatory mediators in healthy male and female athletes according to concussion history and collision sport participation. Eighty-seven university level athletes (male, n = 60; female, n = 27) were recruited before the start of the competitive season. Athletes were healthy at the time of the study (no medications, illness, concussion or musculoskeletal injuries). Dependent variables included 29 inflammatory and 10 neurological injury analytes assessed in the peripheral blood by

SUBMITTER: Di Battista AP 

PROVIDER: S-EPMC4961456 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature