Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.

ABSTRACT:

Objective

The value of cell lines for pre-clinical work lies in choosing those with similar characteristics. Selection of cell lines is typically based on patient history, histological subtype at diagnosis, mutation patterns, or signaling pathways. Although recent studies established consensus regarding molecular characteristics of ovarian cancer cell lines, data on in vivo tumorigenicity remains only sporadically available, impeding translation of in vitro work to xenograft models.

Methods

We introduced 18 ovarian cancer cell lines into athymic nude mice through subcutaneous, intraperitoneal, and ovary intrabursal routes, and observed tumor development over 6weeks. We also profiled cell line gene expression and identified differentially expressed gene sets based on their ab

SUBMITTER: Hernandez L 

PROVIDER: S-EPMC4961516 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature