BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction.

ABSTRACT:

Rationale

We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly induced in the adult heart after experimental myocardial infarction (MI). However, the function of Grem2 and BMP-signaling inhibitors after cardiac injury is currently unknown.

Objective

To investigate the role of Grem2 during cardiac repair and assess its potential to improve ventricular function after injury.

Methods and results

Our data show that Grem2 is transiently induced after MI in peri-infarct area cardiomyocytes during the inflammatory phase of cardiac tissue repair. By engineering loss- (Grem2(-/-)) and gain- (TG(Grem2)) of-Gr

SUBMITTER: Sanders LN 

PROVIDER: S-EPMC4961528 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature