Association between differential gene expression and body mass index among endometrial cancers from The Cancer Genome Atlas Project.

ABSTRACT:

Objective

The Cancer Genome Atlas (TCGA) identified four integrated clusters for endometrial cancer (EC): POLE, MSI, CNL and CNH. We evaluated differences in gene expression profiles of obese and non-obese women with EC and examined the association of body mass index (BMI) within the clusters identified in TCGA.

Methods

TCGA RNAseq data was used to identify genes related to increasing BMI among ECs. The POLE, MSI and CNL clusters were composed mostly of endometrioid EC. Patient BMI was compared between these three clusters with one-way ANOVA. Association between gene expression and BMI was also assessed while adjusting for confounding effects of potential confounding factors. p-Values testing the association between gene expression and BMI were adjusted for multiple hypothes

SUBMITTER: Roque DR 

PROVIDER: S-EPMC4961559 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature