Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway.

ABSTRACT: Fast nerve conduction relies on successive myelin segments that electrically isolate axons. Segment geometry-diameter and length-is critical for the optimization of nerve conduction and the molecular mechanisms allowing this optimized geometry are partially known. We show here that peripheral myelin elongation is dynamically regulated by stimulation of YAP (Yes-associated protein) transcription cofactor activity during axonal elongation and limited by inhibition of YAP activity via the Hippo pathway. YAP promotes myelin and non-myelin genes transcription while the polarity protein Crb3, localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP activity, therefore allowing for optimal myelin growth. Dystrophic Dy(2j/2j) mice mimicking human peripheral neuropathy

SUBMITTER: Fernando RN 

PROVIDER: S-EPMC4961766 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature