Restless Legs Syndrome: Current Concepts about Disease Pathophysiology.

ABSTRACT:

Background

In the past few decades, much has been learned about the pathophysiology of restless legs syndrome (RLS). Investigators have studied neuropathology, imaging, electrophysiology, and genetics of RLS, identifying brain regions and biological systems affected in RLS. This manuscript will review RLS pathophysiology literature, examining the RLS state through consideration of the neuroanatomy, then the biological, organ, and genetic systems.

Methods

Pubmed (1966 to April 2016) was searched for the term "restless legs syndrome" cross-referenced with "pathophysiology," "pathogenesis," "pathology," or "imaging." English language papers were reviewed. Studies that focused on RLS in relation to another disease were not reviewed.

Results

Although there are no gross str

SUBMITTER: Koo BB 

PROVIDER: S-EPMC4961894 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature