Ontology highlight
ABSTRACT:
SUBMITTER: Wong C
PROVIDER: S-EPMC4962038 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20160727
Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulat ...[more]