Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial.

ABSTRACT:

Background

It is unclear whether and at what dose vitamin D supplementation affects insulin resistance (IR).

Objective

We sought to investigate whether vitamin D at doses higher than currently recommended decreases indexes of IR in an ambulatory population of overweight elderly subjects.

Design

This double-blind, randomized, controlled multicenter trial enrolled 257 elderly overweight individuals aged ≥65 y with baseline 25-hydroxyvitamin D [25(OH)D] concentrations between 10 and 30 ng/mL. All subjects received 1000 mg calcium citrate/d, with vitamin D administered weekly at an equivalent dose of 600 or 3750 IU/d. The homeostasis model assessment (HOMA) of IR index at 1 y was the primary outcome. We also assessed the McAuley index.

Results

In total, 222 subject

SUBMITTER: El-Hajj Fuleihan G 

PROVIDER: S-EPMC4962162 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature